Abstract
A S L D A b st ra ct s between NAFLD and colorectal adenoma in asymptomatic patients, who underwent screening colonoscopy. Methods: Electronic database including Pubmed and Embase were searched for relevant studies that investigate the Association between Nonalcoholic fatty liver disease and colorectal adenoma. Study designs and locations in addition to characteristics of adenoma were added to subgroup analysis. The random-effects model was used to pool the effect size across studies and calculated the pooled odds ratio (OR) with 95% confidence interval (CI) for infectious complications. Results: Overall Four cross-sectional studies and three cohort studies with a total of14, 095 subjects were included in the final meta-analysis. The association between NAFLD and colorectal adenoma was statistically significant [pooled odds ratio (OR) 1.42, 95% confidence interval (CI): 1.271-1.587]. The association was more significant in Asian population five studies compared to European/North American population two studies. Conclusions: According to our results in asymptomatic patients undergoing screening colonoscopy, NAFLD is significantly associated with the presence of colorectal adenoma. Our results suggest that extra carful screening for colorectal cancer in patients with NAFLD. The majority of subjects were from Asian country; Further studies of western population might be needed to confirm our results.
Published Version
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