SU-FF-T-217: Evaluation and Validation of GATE-Based Absorbed Dose Calculation for 3D Patient-Specific Internal Dosimetry

Abstract

Purpose: The objective of this study is to validate the use of GATE Monte Carlo simulations to determine patient‐specific dosimetry using quantitative multi‐modality imaging.Method and Materials: Data acquired with the Symbia ™ hybrid SPECT/CT system are reconstructed with Flash‐3D™ and corrected for scatter, collimator detector response and attenuation using a CT attenuation correction method. The voxel‐based CT model is used with GATE to compute 3D dose distributions from the SPECT data. Validation is performed using both simulated SPECT data and anthropomorphic phantoms. Results: Initial validation studies show that GATE, while time consuming, is suitable in dose calculation. Conclusions: The approach presented can be used for radionuclide multi‐modality dosimetry leading to patient‐specific dose calculations for treatment planning.