Sturge-Weber Syndrome Associated with Auditory Hallucination

Abstract

Objective: Sturge-Weber syndrome (SWS) is a congenital neurocutaneous disorder characterized by leptomeningeal angiomatosis, glaucoma, and facial hemangioma. Auditory hallucinations (AH) have not been previously reported in SWS. We report a patient who developed AH after the development of progressive calcification and atrophy of the brain. Case Report: A 33-year-old woman with SWS developed persecutory delusion at 24 years old and AH at 28 years old. Progressive calcification and atrophy of the left temporal lobe were revealed in the series of computed tomography (CT) before and after development of AH. Functional impairment in these areas was verified by neurophysiological and neuropsychological tests. Treatment with 4 mg risperidone daily provided relief for AH and was well tolerated during two years of follow up. Conclusion: It is suggested that progressive brain lesions with calcification and atrophy could account for the development of AH, in cases involving the left temporal or frontal lobes.