Studying the pharmacological safety of the standardized cleared bischofit brine

Abstract

In experiments on mature rats, the pharmacological safety of a purified form of a standardized brine of the mineral bischofite (SBB) was assessed with repeated intragastric administration for 90 days at a dose of 0.01 ml/kg (experimentally proven therapeutic dose). It has been established that the test substance does not have a damaging effect on the general condition of animals (body weight, coat and skin, behavior), hematological and biochemical blood parameters, electrophysiological work of the myocardium, liver and kidney function, does not contribute to changes in the morphostructure of internal organs and brain. In the action of SBB with repeated 90-day administration, the effects of gender differences in behavioral activity (increase in motor and emotional activity in males and decrease in such effects in females) were revealed, electrocardiogram (increased heart rate and amplitude of the "R" wave in males and no changes in females), biochemical parameters (increased glucose levels in males and no changes in females). These changes did not go beyond the physiological norm and completely leveled to the state of control during the 30-day withdrawal of SRP administration.