Abstract
The biological activity of compounds is mostly determined by its physical and structural characteristics. Among the many molecular descriptors that may indicate a potential biological activity of a compound, lipophilicity occupies the most important place. Since chloroacetamides show a variety of physiological activity, the task of this study was to investigate the potential biological activity of newly synthesized derivatives of selected N-substituted phenyl-2-chloroacetamides. Analysis was performed by thin layer chromatography on reversed phase (RP18 F254s TLC), and the mobile phase consisted of mixtures of water-acetic acid and water-dimethylformamide. By varying the volume fraction of organic modifier chromatographic retention constants, R M 0 , of the compounds were determined. Тhen R M 0 were correlated with the software calculated partition coefficient, log P , as a standard measure of lipophilicity. Also, R M 0 were correlated with selected pharmacokinetic parameters: intestinal absorption, HIA , the ability to bind to plasma proteins, PPB, and the distribution through the blood-brain barrier, BBB.
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