Studying catalytic activity of ternary mixed‐metal Keggin H7SiV3W9O40as a versatile acid catalyst for the synthesis of β‐acetamido ketones

Abstract

One‐pot four‐component condensation of an aromatic aldehyde with an enolisable ketone and acetyl chloride is investigated in the presence of H7SiV3W9O40in acetonitrile. The prepared catalyst was characterized by standard techniques such as XRD, SEM, and FT‐IR to verify the Keggin structure of nanocatalyst. Furthermore, findings revealed a very good catalytic activity for the applied vanadium substituted heteropolyacid in this acid catalyzed condensation reaction. A series of Keggin Si and V‐substituted heteropolyacids were compared for the synthesis of β‐acetamido‐β‐(4‐chlorophenyl)propiophenone, which showed a better catalytic activity for H7SiV3W9O40and H4SiW12O40than the lacunary and mixed metal Keggin H4SiW9Mo3O40and H5SiW9Mo2VO40. In addition, effect of the nitrilating agent was also demonstrated in this catalytic system and findings show less proficiency for PhCN compared to acetonitrile. Moreover, propiophenone as an α‐substituted enolisable ketone was reacted with some aromatic aldehydes and the anti isomer is detected as the major diastereomer. Therefore, H7SiV3W9O40can be introduced as a new effective, inexpensive, and eco‐friendly catalyst for the introduced four‐component condensation reaction.