Abstract
A one-pot, three-component condensation of an aryl aldehyde, an enolizable ketone or β-keto ester, acetyl chloride, and acetonitrile or benzonitrile in the presence of magnesium hydrogensulfate as an active, recoverable, and reusable green catalyst is described for the synthesis of β-amido ketones/esters at room temperature. The key features of this methodology are simplicity, mild reaction conditions, and high to excellent yields.Key words: multi-component reaction, magnesium hydrogensulfate, heterogeneous catalyst, β-amido ketone/ester, mild conditions.
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