Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease.

Abstract

In chronic kidney disease (CKD), kidneys develop injured over time and don’t work properly as in the kidneys for healthy people. At what time the kidneys cannot blood clean, further liquids stay and wastes in the body and which leads to many problems in health, such as high blood pressure (BP) and cardiovascular disease (CVD). In current study, we attempt to examine the association of asprosin (APN) and dickkopf-3 (DKK-3) with kidney injury molecule-1 (KIM-1), N-terminal pro-brain natriuretic peptide (NTpro-BNP), growth differentiation factor 15 (GDF-15) and copeptin (CPP) among male Iraqi with CKD. Methods: serum APN, DKK-3, KIM-1, NTpro-BNP, GDF-15 and CPP were determined by ELISA technique in 40 healthy controls (HCs) and 44 male patients with CKD, from the Al-Fallujah teaching hospital were recorded in this paper, serum concentrations of urea, creatinine and estimated glomerular filtration rate (eGFR) were measured by colorimetric methods Results: serum APN and DKK-3 were importantly greater in CKD males than in HCs (P