Abstract
AbstractAdiponectin is a 30-kDa polypeptide chiefly secreted by adipose tissue and plays a pivotal role in cardiovascular complication and kidney disease. The aim of this study was to find if there was any association of adiponectin with inflammation and hypercoagulability in case of type 2 diabetic subjects with renal dysfunction.From May 2012 to January 2014, 205 outpatients with normo, micro, and macroalbuminuria having type 2 diabetes (T2DM) were included in this study.We found a U-shaped association of adiponectin with albumin excretion. Macroalbuminuria showed a positive correlation with adiponectin (p < 0.0001). Plasma F1+2 was strongly associated with degree of renal failure (p < 0.001). CRP, IL6, TNFα, and pentosidine status showed a linear increase from normoalbuminuria and microalbuminuria to macroalbuminuria (p < 0.001, p < 0.0001).Monitoring adiponectin, pasma F1+2, inflammatory and oxidative stress markers provide a predictive value for presence of macrovascular complications in patients wit...
Highlights
Diabetic nephropathy (DN) is an important long-term complication of diabetes (Adler et al, 2003)
Our study has shown the same pattern of association between adiponectin and microalbuminuria in case of T2DM subjects
We noticed that patients with macroalbuminuria on an average had a higher level of adiponectin as compared to the patients with normoalbuminuria and microalbuminuria
Summary
Diabetic nephropathy (DN) is an important long-term complication of diabetes (Adler et al, 2003). Known as Acrp, AdipoQ, gelatin-binding protein of 28 kDa, is an adipocyte-specific protein that enhances insulin sensitivity and promotes lipid metabolism (Díaz-Soto et al, 2014). It circulates in plasma in three forms: a trimer (low-molecular weight [LMW]), a hexamer (trimer-dimer) of mediummolecular weight (MMW), and a larger multimeric high-molecular weight (HMW) form (Scherer, Williams, Fogliano, Baldini, & Lodish, 1995). Cardiovascular disease in DN subject is very frequent Several traditional factors such as dyslipidemia, albuminuria, and hypertension cannot fully explain the progression of this kind of pathogenesis. Prothrombin F1+2, a good marker of thrombin generation in plasma, can be used as a biomarker to assess the risk of developing cardiovascular disease in DN subjects (Aso et al, 2004; Catena, Zingaro, Casaccio, & Sechi, 2000; Shlipak et al, 2003; Tufano et al, 2001)
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