Study protocol for a randomised controlled trial of carvedilol versus variceal band ligation in primary prevention of variceal bleeding in liver cirrhosis (CALIBRE trial)

Dhiraj Tripathi,Khaled Ahmed,Gemma Slinn,Peter Clive Hayes,Peter Devine,Jonathan Mathers,Kelly Handley,Sue Jowett,Margaret Grant,Ian Rowe,Peter Brocklehurst,Paul Richardson,James Ferguson,Christopher Poyner

doi:10.1136/bmjgast-2019-000290

Study protocol for a randomised controlled trial of carvedilol versus variceal band ligation in primary prevention of variceal bleeding in liver cirrhosis (CALIBRE trial)

Dhiraj Tripathi, Khaled Ahmed + Show 12 more

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https://doi.org/10.1136/bmjgast-2019-000290

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Journal: BMJ Open Gastroenterology	Publication Date: Apr 1, 2019
Citations: 15	License type: open-access

Affiliation: University Hospitals Birmingham NHS Foundation Trust, NIHR Birmingham Biomedical Research Centre, Cancer Research UK Clinical Trials Unit, University of Birmingham, University of Edinburgh, University of Leeds, Royal Liverpool University Hospital, University of Liverpool

#Primary Prevention Of Variceal Bleeding #Variceal Bleeding #Bleeding In Liver Cirrhosis #Variceal Band Ligation #Cause Of Adult Deaths #Use Of Healthcare Resources #National Health Service Research Ethics #Crossover Therapies #Health-related Quality Of Life #Internal Pilot

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IntroductionLiver cirrhosis is the fifth largest cause of adult deaths, and a major complication, variceal bleeding is associated with a 1-year mortality of 40%. There is uncertainty on the first-line...

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Study protocol for a randomised controlled trial of carvedilol versus variceal band ligation in primary prevention of variceal bleeding in liver cirrhosis (CALIBRE trial)