Study progress of chronic intestinal pseudo-obstruction in children

Abstract

Chronic intestinal pseudo-obstruction(CIPO) is an intestinal motility dysfunction caused by intestinal myopathies or neuropathies or mesenchymopathies.The clinical manifestation is almost the same with mechanical intestinal obstruction, but in the absence of any obstruction in the gastrointestinal tract.According to etiology, it can be divided into primary and secondary.While according to gastrointestinal neuromuscular disorders, it can be categorized as myopathy, neuropathy and mesenchymopathy, which have different pathogenesis.The disease with the clinical manifestation, imaging examination or histopathology was diagnosed, but mechanical intestinal obstruction must be excluded.Presently, the therapies of CIPO mainly are stimulating the motility of intestine and ensuring the necessary nutrition of the children.The review is mainly focused on the research progress of the pathogenesis, clinical manifestation, diagnosis, therapy of pediatric CIPO in recent years. Key words: Chronic intestinal pseudo-obstruction; Pathogenesis; Diagnosis; Therapy; Child