Study on the relationship of the T cell receptor constant alpha chain gene (TCRCα) loci-575 A/G polymorphisms and Henoch-Schonlein purpura (HSP) in Changsha Chinese Children

Abstract

Objective To investigate the genetic polymorphisms of the T cell receptor constant alpha chain gene (TCRCα) loci-575 A/G in Hunan Han Chinese children with Henoch-Schonlein purpura (HSP).Methods Thirty-six cases of patients with HSP and 60 healthy children as controls were investigated in this study.The T cell receptor constant alpha chain gene (TCRCα)loci-575 A/G was detected with polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP).Results The genotype frequencies of AA,AG,and GG in the locus-575 A/G of TCRCα gene were 22.2％,47.2％,and 30.6％ in HSP patients,and 28.3％,50.0％,and 21.7％ in control group; and no significant differences were found between HSP patient and control groups (P ＞ 0.05).The allele frequencies of A and G were 45.8％ and 54.2％ in HSP patients,and 53.3％ and 46.7％ in control group; and no significant differences were found between HSP patient and control groups (P ＞ 0.05).Conclusions The polymorphism of locus-575 A/G of T cell receptor constant alpha chain gene had not been found association with HSP. Key words: Genes,T-cell receptor; Polymorphism,single nucleotide; Purpura,schoenlein-henoch; HAN NATIONALITY; Child; HUNAN