Study on the relationship between insulin resistance and thyroid nodule in 105 cases of normal glucose metabolism

Abstract

Objective To study on the relationship between insulin resistance and thyroid nodule in the patients of normal glucose metabolism. Methods The clinical data of 105 patients of normal glucose metabolism were analyzed. The patients were divided into nodules group (54 patients) and non- nodules group (51 patients). The age, sex, body mass index (BMI), fasting plasma glucose (FPG), postprandial 2 h blood glucose (2 h PG), fasting insulin (FINS), postprandial 2 h (2 h INS), fasting C peptide (FC-P), postprandial 2 h C peptide (2 h C-P), glycosylated hemoglobin (HbA1c), blood uric acid (BUA), homeostatic model assessment insulin resistance index (HOMA-IR) were compared between two groups. According the level of HOMA- IR, 105 patients were divided into different subgroups, the detection rate of thyroid nodules was compared. The influencing factors of thyroid nodules were analyzed by multi- factor Logistic regression analysis. Results The age and sex between two groups had no significant differences (P > 0.05). The levels of BMI, BUA, HOMA-IR, FPG, FINS, 2 h INS, FC-P, 2 h C-P and HbA1c in nodules group were significantly higher than those in non- nodules group (P 4.00 group (20/20) was higher than that in HOMA- IR 0- 1.00 group (0), HOMA- IR 1.01- 2.00 group (39.5%, 17/43) and HOMA-IR 2.01 - 3.00 group (5/17), there were significant differences (P 0.05). Conclusions The detection rate of thyroid nodules in HOMA-IR > 3.00 patients is significantly higher. The insulin resistance, higher BMI and hyperuricemia are the independent risk factors of thyroid nodules. Key words: Thyroid nodule; Uric acid; Insulin resistance; Body mass index