Study on the relation between anti β2-glycoprotein I antibodies and recurrent abortion

Abstract

Objective To explore the relation between anti β2-glycoprotein I antibodies and recurrent abortion. Methods This study collected the clinical data of 210 recurrent abortion patients with anticardiolipin antibody negative and 80 normal multiparas, who were admitted in the Shandong Provincial Hospital Affiliated to Shandong University from January 1st to December 31st 2012. To explored the level of anti β2-glycoprotein I antibody immunoglobulin M (IgM) for treating the recurrent abortion, serum anti β2-glycoprotein I antibodies of the patients were collected and anticoagulant therapy effects of the recurrent abortion patients were analyzed. Results (1) The recurrent abortion patients were related with anti β2-glycoprotein I antibody IgM. Among the 210 recurrent abortion patients, 48 patients were anti β2-glycoprotein I antibody IgM positive; the incidence rate was 22.9%. (2) For the recurrent abortion patients with 15-20 RU/ml anti β2-glycoprotein I antibody IgM, the successful pregnancy rate in anticoagulant therapy group (66.7%, 14/21) were significantly higher than that in control group (19.4%, 6/31), ( χ2=11.840, P value <0.05). (3) For the recurrent abortion patients with equal or more than 15 RU/ml anti β2-glycoprotein I antibody IgM, the successful pregnancy rate in anticoagulant therapy group (70.6%, 36/100) were significantly higher than that in control group (18.4%, 9/49), ( χ2=27.535, P value <0.05). Conclusions There was relation between recurrent abortion patients and anti β2-glycoprotein I antibody IgM. When anti β2-glycoprotein I antibody IgM was equal or more than 15 RU/ml, the recurrent abortion patients should be treated with anticoagulant therapy. Key words: Abortion, habitual; Anti β2-glycoprotein I antibody; Therapy