Study on the prediction of premature rupture of membranes with inhibin A

Abstract

Objective To explore the relationship between the level of the pregnant women serum inhibin A and premature rupture of membranes. Methods Thirty-two pregnant women with the gestational age 36-37+6 weeks were selected, including 18 cases with premature rupture of membranes (premature rupture of membranes group) and 14 cases without premature rupture of membranes (none premature rupture of membranes group). The serum level of inhibin A was measured by enzyme-linked immunosorbent assay method. Results The serum level of inhibin A in premature rupture of membranes group was significantly higher than that in none premature rupture of membranes group (1 253.5 ng/L vs. 698.1 ng/L), and there was statistical difference (P<0.05). The receiver-operating characteristic curve analysis result showed that the optimal cut-off value of serum level of inhibin A to predict premature rupture of membranes was 984.45 ng/L, with a sensitivity of 72.2% and a specificity of 78.6%, and the area under the curve was 0.77 (95% CI 0.59-0.95). Conclusions The serum level of inhibin A has a certain predictive value for premature rupture of membranes. Key words: Fetal membranes, premature rupture; Inhibins; Term birth