Study on the mechanism of anti-cancer action of rosa roxbughii tratt based on network pharmacology

Abstract

The active chemical components and targets of rosa roxbughii tratt were screened by the method of network pharmacology, and the molecular mechanism of its action was discussed. By consulting relevant literature reports, we established drug-disease targets by using databases such as TCMSP, TCMIP, Genecards and OMIM. Using STRING database to construct the protein interaction network between rosa roxbughii tratt and cancer target; and Cytoscape software was used to construct the interactive network diagram of “active ingredient-target-disease”. The function enrichment analysis of Gene Ontology (GO) and pathway enrichment analysis based on Kyoto Encyclopedia of genes and genomes (KEGG) were carried out by using biological information annotation database (David). We obtained 11 active components and 80 drug-disease targets were obtained, DAVID database was used to carry out GO function enrichment analysis and KEGG pathway enrichment analysis on 80 potential targets, and 303 biological processes and 114 signaling pathways were screened out to participate in the anti-cancer effect of rosa roxbughii tratt. The Pathway in cancer has the strongest correlation with cancer, which is related to the regulation of IL6, AR, CASP3 and other key genes. These key genes are related to myricetin, quercetin, kaempferol and other compounds in rosa roxbughii tratt. The anti-cancer compounds of rosa roxbughii tratt might were myricetin, quercetin, kaempferol and other compounds. The anti-cancer effect of rosa roxbughii tratt may regulation of key genes, indirectly affecting the sustained angiogenesis, developing apoptosis and promotion, so as to promote or inhibit the production of cancer.