Study on the Intervention Effect of Qi Gong Wan Prescription on Patients with Phlegm-Dampness Syndrome of Polycystic Ovary Syndrome Based on Intestinal Flora.

Ning Zhang,Hai-Cui Wu,Chang Li,Ying Guo,Carmen Mannucci

doi:10.1155/2020/6389034

Abstract

Objective This was a population-based cohort study, to compare the type and structure of intestinal flora in patients with polycystic ovary syndrome (PCOS) with phlegm-dampness syndrome, nonphlegm-dampness syndrome, and normal population. Besides, changes in the intestinal flora and the clinical curative effects of Jiawei Qi Gong Wan on phlegm-dampness syndrome in patients with polycystic ovary syndrome (PCOS) were evaluated. Patients and Methods. A total of 22 patients with PCOS with phlegm-dampness syndrome, 21 PCOS patients with nonphlegm-dampness syndrome, and 20 control volunteers were selected for this study. The general index, sex hormone index, fasting blood glucose (FPG), and serum fasting insulin (FINS) were determined in each of the groups. The intestinal flora of each group was determined by the 16s rDNA high-throughput sequencing technique. Besides, the PCOS with phlegm-dampness syndrome group was treated with Jiawei Qi Gong Wan, and the changes in TCM syndrome, sex hormone index, BMI, WHR, FPG, FINS, HOMA-IR, and intestinal flora were determined before and after treatment. Results PCOS patients with phlegm-dampness syndrome showed characteristics of obesity and insulin resistance. There were several differences in both structure and function of the intestinal flora between PCOS patients with phlegm-dampness syndrome, PCOS patients with nonphlegm-dampness syndrome, and the control group. An imbalance in the intestinal flora may be a key factor in the pathogenesis of PCOS with phlegm-dampness syndrome and also has a specific influence on glucose and lipid metabolism, obesity, and the menstrual cycle in PCOS patients with phlegm-dampness syndrome. Besides, the imbalance is associated with a decrease in the number of butyrate-producing bacteria, an increase in the number of lipopolysaccharide-producing bacteria, and an increase in proinflammatory bacteria. The intestinal flora in PCOS patients with phlegm-dampness syndrome was found to be linked to obesity, impaired glucose tolerance, and hyperandrogenemia. Treatment with Jiawei Qi Gong Wan was found to increase the diversity of intestinal flora, increase the number of intestinal probiotics, and improve the structure and functional genes of intestinal flora which improved the state of insulin resistance, regulated endocrine metabolism, and improved the overall symptoms. Conclusions Intestinal flora imbalance is a key factor in the pathogenesis of PCOS with phlegm-dampness syndrome. Besides, Jiawei Qi Gong Wan improves insulin resistance which is linked to the status of the intestinal flora in PCOS patients with phlegm-dampness syndrome.

Highlights

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women aged between 18 and 44 years of age
Characteristics of the Study Subjects. e clinical and hormonal parameters are summarized in Table 1. e results showed that age, follicle-stimulating hormone (FSH), E2, P, and PRL did not differ between the groups
body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), fasting plasma glucose (FPG), fasting insulin (FINS), and homeostasis model assessment (HOMA)-insulin resistance (IR) were higher in the PCOS with phlegm-dampness group than in the PCOS with nonphlegm-dampness group and the control group (P < 0.05). e luteinizing hormone (LH), LH/FSH, and T were higher in both the PCOS with phlegm-dampness group and the PCOS with nonphlegm-dampness group than the control group, and the differences were statistically significant (P < 0.05)

Summary

Introduction

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women aged between 18 and 44 years of age. Menstrual abnormalities, hyperandrogenism (HA), obesity, rare ovulation or anovulation, and insulin resistance (IR) are some of the main features of PCOS. Ye Tianshi, an ancient Chinese physician, put forward the importance of physical factors in disease differentiation and syndrome differentiation. He further noted that dampness is a yin pathogenic factor; it tends to descend and attack the yin body sites; and it is turbid, sticky, and lingering and tends to affect first the lower part of the body, causing abdominal fullness. He further noted that dampness is a yin pathogenic factor; it tends to descend and attack the yin body sites; and it is turbid, sticky, and lingering and tends to affect first the lower part of the body, causing abdominal fullness. e phlegm-dampness constitution is one of the main pathogenesis common in obese people

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Results

Conclusion