Study on the influence of warfarin on chronic subdural hematoma

Abstract

Objective To investigate the influence of anticoagulant drug warfarin on chronic subdural hematoma (CSDH) and the role in CSDF recurrence.Methods 136 patients with CSDH hole drainage surgery were selected.The clinical data were analyzed and the patients were followed up.INR level and the correct time in patients only used VK or used VK + PCC were compared between the two groups before and after treatment.The history of trauma,the recurrence rate,time to recurrence in patients received warfarin therapy or not were compared.Results The time of anticoagulated indicators INR dropped to normal was (6.4 ± 4.9)h in VK + PCC group,which was significantly shorter than in the VK group(14.5 ±7.6)h(P ＜0.05).In patients not received warfarin preoperatively,52 cases(57％) had a history of traumatic brain injury.12 patients (27％) had the history of traumatic brain injury in patients received warfarin preoperatively.The proportion of patients with a history of traumatic brain injury in without warfarin therapy group was significantly higer than the anticoagulant therapy group (P ＜ 0.05).A total of 18 cases(13％) had postoperative recurrence,they were given the CSDH drilling drainage again.The recurrence rate be tween the warfarin anticoagulant group (18 ％) and non-anticoagulant group (11％) had no significant difference P ＞0.05).Time to relapse in patients with preoperative use of warfarin therapy and without anticoagulant therapy was (20.5 ±8.1)d,(24.4 ± 13.2)d (P＞0.05).Conclusion Warfarin increased the possibility of non-traumatic CSDH,VK + PCC shortened the corrective warfarin anticoagulation time required. Key words: Hematoma, subdural, chronic; Anticoagulants; Warfarin