Abstract
It can be observed that oxidative stress initiates and aggravates many diseases, including peptic ulcers and gastric carcinoma. An increase in rat mucosal glandular lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in gastric ulceration induced by cold retention stress were observed, whereas in patients with ulcerated clinical peptic and gastric carcinoma LPO serum is associated with a decrease in SOD and CAT. It was intended to determine the parameters of oxidative stress in the blood and brain in rats after induction of gastric ulcer, the effect of antioxidant treatment on these parameters and on the appearance of gastric ulcer, determination of correlation between oxidative stress and severity of gastric ulcer in rats and also evaluation of vascular endothelial function by in vitro studies in the organ bath, from rat aortic rings with gastric ulcer vs. normal and others under treatment vs. untreated.
Highlights
It can be observed that oxidative stress initiates and aggravates many diseases, including peptic ulcers and gastric carcinoma
After animal sacrifice we followed the macroscopic evaluation of gastric-induced lesions (Figure 1), as well as the determination of superoxide dismutase (SOD) and catalase from the lysis of the brain
This study demonstrated antioxidant therapy possessing a strong protective activity on the gastric mucosa, which results in a reduction in lipid peroxidation and a decrease in the inflammatory process
Summary
It can be observed that oxidative stress initiates and aggravates many diseases, including peptic ulcers and gastric carcinoma. Determination of superoxide dismutase in blood The SOD measurement was performed following the procedure of Sun et al (34). Determination of catalase in brain To measure CAT activities, we used 5% cytosol (50 mg brain tissue in 1 mL 0.1 M phosphate buffer pH 7.4 and centrifuged under cooling at 20-30 thousand r.p.m for 30 min).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
