Abstract
Corona charged electrets at voltages of +500 V, +1000 V and +1500 V were prepared for manufacturing polypropylene (PP) electret blank patches and PP electret drug patches. The stability of external electrostatic field of the electret patch and the polarization of the drug in patch under the internal electrostatic field of the electret were studied. The results indicate that all the electret drug patches had good charge storage stabilities. However, the non-electrode coated electret drug patch had better stability in the external electrostatic field than that of the electrode coated electret drug patch. The higher the charging voltage of the electret, the faster the surface potential of the electret drug patch decayed, and the worse the stability of the external electrostatic field. All the electrets used in this study could result in the polarization of the model drug in patch. The piezoelectric properties of non-electrode coated electret drug patch increased with the charging voltage of the electret. However, excessively higher charging voltage could result in the decreased polarization of the drug in patch. Both the stability of the external electrostatic field of electret and the polarization of drug were the key factors for controlled drug release and skin permeation.
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