Abstract
Objective To study the diagnostic method of microcirculation disturbance of patients with chronic hepatitis B (CHB).Methods 81 patients with CHB and 5 normal volunteer were observed.Hypoxia-induciable factor was detected by immunohistochemistry stain,TXB2 and 6-Keto-PGF1α were detected by chemiluminescence and HA was detected by RIA,ultrastructure of liver was observed by transmission electron microscope (TEM).Results Accompany with the pathological changes of liver in patients with CHB,the strength and range of expression of HIF-1 α enhanced,HA and TXB2 of serum rised gradually( all P ＜ 0.05 ),but 6-Keto-PGF1α of blood plasma fell- off.The electron microscope showed that erythrocyte aggregation,stenosis and blockage of sinus hepaticus turned obviously,collagen fibers deposition and basal membrane formation aggravated gradually.Conclusion Associated detec tion with HIF-1 α、HA 、TXB2 and 6-Keto-PGF1 α can reflect the condition of microcirculation of liver perfectly. Key words: Hepatitis B, chronic ; Hypoxia-induciable factor; Microcirculatory disturbance; Sinusoidal endothelial cell
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