Study on the correlation between mechanical characteristics of respiratory system and gastroesophageal reflux in patients with OSAHS

Abstract

Objective To explore the possible mechanism of gastroesophageal reflux in patients with obstructive sleep apnea hypopnea syndrome(OSAHS), this study evaluated the correlation between the mechanical characteristics of therespiratory system and the degree of gastroesophageal reflux in patients with OSAHS. Methods From February 2014 to February 2016, the suspected OSAHS patients admitted to hospital for the first timein People′s Hospital of Xinjiang Uygur Autonomous Region, were performed routine pulmonary function testand polysomnography(PSG), pulse oscillation system(IOS), 24h multi-channel impedance-pH monitoring system.The inclusion and exclusion criteriawereformulated.259 cases of suspected patients, 182 cases were diagnosed as OSAHS, and 77 cases were non-OSAHS patients; 127 cases of OSAHS patients with pathological gastroesophageal reflux(group A); 55 cases of OSAHS patients with abnormal gastroesophageal reflux(group B); 23 cases of non-OSAHS patients with pathological gastroesophageal reflux(group C); 54 cases of non-OSAHS patients without pathological gastroesophageal reflux(group D). The differences between the two groups were compared and analyzed. Results Group A, group B, group C and group D of BMI, AHI and LSaO2 had significant differences(P<0.05); Compared with group B, group C and group D, FRC and ERVof group A were significantly decreased, and had significant differences(P<0.05); the Zrs5 and all of the oscillation frequency of Rrswere significantly increased, and Xrswas significantly decreased.The differences were statistically significant(P<0.05); the total number of esophageal reflux, proximal esophageal acid reflux index and DeMeester score in group A was significantly higher than that of groupB, C and D(P<0.05); correlation analysis showed that OSAHS patients with Zrs5 and 5 to 15 Hz Rrs and the total number of reflux and DeMeester score were decreased in OSAHS Xrs5; the total number of reflux, DeMeester score was negatively correlated. Conclusion The mechanical characteristics of therespiratory system in OSAHS patients were changed, the respiratory resistance increased and the elastic characteristics of the respiratory system, especially the decrease in lung compliance was related to the gastroesophageal reflux. Key words: Sleep apnea, obstructive; Gastroesophageal reflux; Pulse oscillation system; Mechanical characteristics of respiratory system