Abstract
Abstract An effort has been initiated to design pharmacophore-based 3D models pertaining to human RACK1 protein, (receptor of activated kinase-1) inhibitors were generated with accurate predictability. Such lead compounds were subsequently validated by screening measures to determine its biological activities and its adaptable stability in the systems. The benchmark for virtual screening was also treated to examine the selective RACK1 inhibitors. As a result of virtual screening experiment and in vitro evaluation of lead candidate compounds, resulted novel and appropriate RACK1 inhibitors were recognized. Therefore, the findings of the present investigation will be through a light on an innovative strategy for identifying biological adaptable RACK1 inhibitors to control or arrest the proliferation of tumor cells using in vitro studies. Molecular Docking studies were performed to understand the capability of RACK1 inhibitor activity and to explore its high interactive accord or affinity.
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