Abstract
The effect of a cardiotonic agent, MCI-154, 6-[4-(4’-pyridylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride trihydrate, is a Ca2+ sensitizer on the contractile properties and adenosine triphosphatase ATPase activity on skeletal muscle fibers. As in cardiac m uscle, MCI-154 potentiated isometric tension and improved isometric tension cost at full Ca2+ activation. However, MCI-154 decreased all the kinetic parameters. The MCI-154 improves not only cardiac systolic function but also diastolic relaxation in CHF. The possible mechanisms are Ca2+ transient and cell shortening in ventricular myocytes and also L-type Ca2+ current and Na+/Ca2+ exchange current. The MCI-154 exhibited hemodynamic, inotropic, mechano-energetic and oxidative metabolic effects.
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