Study on preparation and slow release properties of Magnesium-Al hydrotalcite with alanine intercalation

Abstract

The precursors of Mg-Al hydrotalcite (Mg/Al-LDHs-NO3) were prepared by low saturation coprecipitation method (constant pH method). In addition, alsine-intercalated magnesium-aluminum hydrotalcite (LDHs-Ala) was synthesized by low saturation coprecipitation (constant pH) and nucleation/crystallization isolation methods when the pH value was higher than the isoelectric point of alanine. The release properties of alanine intercalated hydrotalc in simulated gastric fluid (hydrochloric acid solution with pH=1.5) and intestinal fluid (phosphate solution with pH=7.4) were measured by spectrophotometer in vitro. The results showed that LDHs-Ala had good slow-release properties in simulated intestinal fluid and gastric fluid in vitro. Then sodium alginate was used to coated alanine intercalated hydrotalc for slow release in simulated intestinal fluid and simulated gastric fluid. It can be concluded that the coated intercalated hydrotalc has a low slow release rate in gastric fluid, but has a good slow release performance in simulated intestinal fluid. It can be concluded that the coated intercalated hydrotalc is expected to be a intestinal targeted release agent, which can be applied in biomedicine.