STUDY ON PLASMA LEPTIN LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH OVERWEIGHT OR OBESITY

Abstract

Objectives: To investigate plasma leptin level and its association with some risk factors in type 2 diabetes mellitus (T2DM) patients with overweight or obesity. Subjects and methods: A cross-sectional descriptive and comparable study was conducted on 266 patients assigned into three groups, including T2DM patients with overweight or obesity (study group, n = 104), non-overweight/non-obese atients with T2DM (disease-control, n = 109) and healthy control subjects (n = 53). Plasma leptin levels were quantified with ELISA Kit at the Department of Pathophysiology, Vietnam Military Medical University. Results: For type 2 diabetic patients with obesity/overweight, we found no significant difference in plasma leptin levels between the study group and the disease-control and healthy subjects (0.43; 0.35-0.53 ng/mL vs 0.42; 0.34-0.52 ng/mL and 0.46; 0.36-0.60 ng/mL, respectively) with p > 0.05. In the overweight or obese diabetic patients, there was a positive correlation of leptin levels with age (r = 0.228; p = 0.02), waist circumference (WC) (r = 0.638; p < 0.001), hip circumference (HC) (r = 0.473; p < 0.001), W/H (r = 0.471; p < 0.001) and serum creatinine levels (r = 0.508; p < 0.001). Additionally, plasma leptin levels were higher in overweight/obese patients who were diabetic for more than 5 years (0.47 ± 0.16 ng/mL) than in those with diabetes less than 5 years (0.38 ± 0.15 ng/mL) (p < 0.05). Significantly higher blood leptin levels were noted in the group with hypertension than in normotensive individuals (p < 0.05).