Abstract
Antibodies of spontaneous (reaginic) and induced (anaphylactic) immediate wheal and erythema type of sensitivity and human ragweed-blocking antibody were tested for their ability to induce passive cutaneous anaphylaxis (PCA) in guinea pig skin. 1. 1. None of the sera of the spontaneous immediate wheal and erythema sensitivity (against pollens, horse epithelium, and horse serum) were capable of producing passive sensitization of guinea pig skin, although each exhibited a strong positive Prausnitz-Küstner reaction. 2. 2. Positive PCA was obtained only with sera from the induced type of immediate wheal and erythema sensitivity against horse serum in human beings and ragweed pollen in rabbits. However, the human sera containing induced blocking antibody to ragweed did not produce positive PCA reactions, although each manifested good blocking activity in inhibition tests. Thus, the PCA in the guinea pig by transfer of human serum could be considered as evidence in favor of immunologic distinction between antibodies of the spontaneous immediate wheal and erythema type of sensitivity (human skin antibodies known as reagins), antibodies of the induced immediate wheal and erythema type of sensitivity (skin-sensitizing antibodies with anaphylactic property), and the human blocking antibodies.
Published Version
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