Study on neuroendocrine changing of post-TBI

Abstract

Objective To observe the change of the male patient's neuroendocrine hormone in serum after medium and severe TBI.Method 95 male patients were selected from our hospital and their GCS were all under 12(without endocrine disease).They were phlebotomized 1 d,3 d,7 d,14 d,21 d after injury and we preserved their serum in refrigerator under-80℃ after centrifugalization.PGN,COR,T3,T4,E2,TES,FSH,GH,INS,LH,PRL,TSH,ACTH were detected by the automate chemiluminescence machine.According to the reference ranges,the indexes detected at different times can be classified and with calculation we got the rate which may be higher,lower than the normal level demonstrated by the diagram.Results The rate of the change which occured at the male patient's endocrine hormones after medium and severe TBI is high.The levels of T3,T4 mostly decreased at first,then restored to the normal level:FSH and LH may be high or low,mostly showed to increase:PRL and E2 demonstrated to increase:PGN increased only for a short time;INS abnormal patient mainly increased;GH increased obviously;COR mainly increased,but at a few circumstance it may decreased:TES decreased obviously:ACTH abnormal patient mainly increased.Conclusions The rate of the neuroendocrine changes which occurred after TBI is high and it will accelerate the recovery of the patients after taking the related therapies. Key words: Neurosecretory systems; Craniocerebral trauma