Abstract
Based on prediction model for thrombus proposed by Grigioni and Danny Bluestein, the mechanism for preventing thrombus formation by a Nano-biological catheter pump was studied herein by applying computational fluid dynamics (CFD). The shearing force and exposure time for platelets during the movement of nano-biologic catheter pump were calculated, and the platelet activation state (PAS) was analyzed, so as to simulate thrombus formation of Nano-biologic catheter pump, predict the thrombus formation and prevent the occurrence of thrombus. Through calculation and analysis, it was shown that the pump can meet the requirements for left ventricle pump when the flow rate of the Nano-biological catheter pump is 3.8 L/min, the rotation speed is 9800 r/min and the head is 14.798 kPa. PAS in the prediction model by Grigioni and Danny Bluestein were 6.39 × 10–6 and 7.68 × 10–4, respectively. Since the values were small, the thrombus almost never formed. To explore the mechanism for preventing thrombus formation, and prediction of hydraulic performance of the pump can provide theoretical basis for optimizing the structure of the pump.
Published Version
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