Study on Levodopa Sensor Modified by Ti3C2 MXene

Abstract

The dosage management of levodopa is of great significance in the treatment of Parkinson’s disease. Measuring the patient’s levodopa concentration helps the physician to adjust the dose in time, so as to avoid complications. In this paper, we report an electrochemical sensor based on titanium carbide (Ti3C2) MXene nanomaterials, which can sensitively reflect the change of levodopa concentration. In the study, Ti3C2/GCE electrode was prepared by a simple drop-coating method, and then the Ti3C2/Pt/GCE electrode was prepared by modifying Pt nanoparticles on the electrode surface by impregnation adsorption method. After modification, the response of the GCE electrode to levodopa before and after Ti3C2 decoration was compared by cyclic voltammetry (CV), and the diffusion control process on the electrode surface was also investigated. Then, differential pulse voltammetry (DPV) was used to explore the relationship between the peak current of the oxidation anode and the concentration of levodopa. Finally, the relationship between current and concentration at a certain time point was explored by chronoamperometry (CA), and the time charge curves were plotted to explore the functional relationship between the amount of charge exchanged in the reaction and the concentration of levodopa (Coulomb analysis method). The research shows that the coulomb analysis method has a higher detection sensitivity and linear range, and this technology is expected to be applied to the in vivo monitoring of levodopa in our future research.