Abstract
Pure and Cadmium (Cd) doped Cerium oxide nanoparticles (CeNPs) have been synthesised by the simple chemical co-precipitation technique. Cadmium ions of concentrations 1, 3 and 5 mol% were doped to investigate their influence on the structural and optical properties of CeO2. The synthesised samples have been subjected to X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis and high-resolution transmission electron microscopy (HRTEM). The XRD and Raman patterns have witnessed the cubic structure of the cerium oxide nanoparticles. The average particle size of CeO2 was found to be around 10 nm. SEM image has also ascertained that the grain size of pure CeO2 appeared is bigger than that of the Cd-doped, which intern indicates the grain growth upon doping. Besides, the antibacterial activity of the cadmium doped cerium oxide nanoparticles against some human pathogens revealed that they have exhibited the maximum zone of inhibition against gram-positive bacteria than the gram-negative species. Further, the cytotoxic effect of Cd-doped CeO2 sample is examined in cultured (MCF-7, A549 and Hep-2) cell.
Highlights
Of late, nanotechnology has been the primary focus, especially, on biomedical related research activities
The synthesised samples have been subjected to X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis and high-resolution transmission electron microscopy (HRTEM)
Breast cancer cells (MCF-7), Human Lung cancer cells (A549) and Human Larynx Carcinoma cancer cells (Hep-2) were obtained. These cell lines were grown as a monolayer in Dulbecco’s modified Eagle’s medium (DMEM: Himedia Laboratories, Mumbai, India), medium which was supplemented with 10% fetal bovine serum, 100 U/mL penicillin, and 100 μg/mL streptomycin (Hi Media Laboratories Mumbai, India) cells grown at 37 ̊C in incubator under 5% CO2 with high humidity [18] [19] [20]
Summary
Nanotechnology has been the primary focus, especially, on biomedical related research activities. It has been well demonstrated that the nanomaterial’s exhibited several interesting properties and they were exploited in the field of life science research, biology and medicine [1]-[6]. These nanomaterials find a wide range of applications which include luminescent biomarkers, drug delivery systems, tissue engineering, etc [7]. Cerium oxide nanoparticles (CeNPs) originated from the variable valence states (3+ and 4+) of cerium element. CeO2 nanoparticles were prepared by several methods namely; hydrothermal synthesis [14], Co-precipitation technique [15] and Solvothermal Methods [16] [17]. The biological activity against certain human pathogen was analysed
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