Abstract
Uterine natural killer (uNK) cell is a kind of immune cells located in female uterine, whose main phenotype is CD56brightCD16-. It has a great immunomodulatory effect and relatively weak cytotoxicity during normal early pregnancy. It has played a significant role during the process of embryo implantation, including the secretion of cytokines and growth factors, promoting the invading of trophoblast cells into decidual as well as the angiogenesis of decidual and placenta, et al. It is considered that the abnormity of uNK cell’s function and amout is related to many gestational diseases, such as repeated implantation failure, preeclampsia, et al. The objective of this review is to summarize the latest researches about uNK cell in order to understand more about the mechanism of the related diseases, and to guide the clinical prevention and treatment. Key words: Uterine natural killer (uNK) cell; Implantation; Secretion; Angiogenesis; Recurrent spontaneous abortion; Preeclampsia
Published Version
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