Abstract
Aim: 1,25-DihydroxyvitaminD3 (1,25(OH)2D3), the active form of vitamin D, mediates antitumor effects mostly by the vitamin D nuclear receptor (VDR) in various cancers. We aimed to examine mRNA and protein expression differences of 1,25(OH)2D3-inactivating CYP24A1 and mRNA expression of the activating CYP27B1 enzymes, as well as that of VDR between human non-tumorous liver and hepatocellular carcinoma (HCC) tissue samples, and to study the correlation with clinicopathological characteristics.
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