Study of the Structure–Activity Relationship in a Heterogeneous Copper–Palladium Catalysed Suzuki–Miyaura Coupling

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Copper–palladium bimetallic catalyst supported on 4 A molecular sieve prepared with two-step wet impregnation was successfully applied in the Suzuki–Miyaura reaction. The reaction took place with a variety of substituted boronic acids as well as with a collection of iodo- and bromobenzene derivatives. In some cases steric effects had influence on the reaction, ortho-substituted iodo- or bromobenzenes gave lower yield independently from the substituent. But most m- and p-substituted iodo- and bromobenzenes showed good to excellent activity. Several biphenyls were obtained by two or even three pathways: either the boronic acid or the respective iodo- or bromobenzene was functionalised.