Abstract
Background:The relationship between the expressions of matrix metalloproteinases with clinico-pathological data on gastric cancer has been investigated in many countries, but this relationship remains unexplored in Iranian patients. Also, the correlation of the MMPs and the HER-2/neu proto-oncogene with other clinic-pathological variables has been evaluated for several other malignancies, but little effort has been made to shed light on the relationship with gastric cancer. Methods:We investigated MMP-2 and MMP-9 expression and HERE-2/neu overexpression in 48 gastric cancer patients referred to Afzalipour Hospital, associated with Kerman Medical University. Immunohistochemistry staining with rabbit polyclonal antibodies was used. Data statistical analysis was done by SPSS software (Version 20.0).Results:The mean age was 59, most of the patients were male (79.2%), and the average tumor size was larger than 5 centimeters in its greatest diameter. The majority of tumors were of the intestinal subtype and were located in the pyloric and antrum regions (43.8%). Invasion to muscularis properia was seen in 87.5% of the tumors (T3). MMP-2 and MMP-9 were highly expressed in 58.3% and 50% of cases, respectively, and Her-2/neu positivity was 10.4%. MMP-2, MMP-9 and HER-2 were found to have no relation with any clinicopathological parameters. Conclusion: According to the results of this study, MMP-2 and MMP-9 were highly expressed in gastric cancer, but there was no significant association with other clinicopathological variables.
Highlights
According to GLOBOCAN’s (Global Cancer Observatory) 2018 data, gastric cancer incidence has decreased in recent years, gastric cancer is still the third leading cause of death from cancer worldwide (Bray et al, 2018)
We investigated Matrix metalloproteinases (MMPs)-2 and MMP-9 expression and HERE-2/neu overexpression in 48 gastric cancer patients referred to Afzalipour Hospital, associated with Kerman Medical University
According to the results of this study, MMP-2 and MMP-9 were highly expressed in gastric cancer, but there was no significant association with other clinicopathological variables
Summary
According to GLOBOCAN’s (Global Cancer Observatory) 2018 data, gastric cancer incidence has decreased in recent years, gastric cancer is still the third leading cause of death from cancer worldwide (Bray et al, 2018). Two key members of the MMP family are matrix metalloproteinase-2 (MMP-2, 72-kDa gelatinase, called type IV collagenase) and matrix metalloproteinase-9 (MMP-9, 92-kDa gelatinase, called type IV collagenases) (Sheu et al, 2003; Odaka et al, 2005) The overexpression of these two markers has been reported in several tumors such as ovarian cancer, cervical cancer, hepatocellular cancer, head, neck, and thyroid carcinomas, squamous cell carcinomas, and gastric cancer. HER2 is expressed in many tissues, including the breast, the gastrointestinal tract, the kidneys, and the heart It plays a major role in tumorigenesis by promoting cell proliferation and suppressing apoptosis, facilitating excessive/uncontrolled cell growth and cancerization (Neve et al, 2001; Rubin and Yarden, 2001; Ménard et al, 2003). To the best of our knowledge, this is the first study to assess the expression of matrix metalloproteinases in Iranian patients suffering from gastric cancer
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