Abstract
The works show that, using fluorescent probes, it was used to study the effect of PC-8 on changes in the dynamics of the intracellular Ca2+ content in synaptosomes of the rat brain, depending on the site of the binding of glutamate on calcium channels by a specific mediator with glutamate. To measure the amount of cytosolic Ca2+ synaptosomes, we calculated using the Grinkevich equation. It has been shown that polyphenol PC-8 binds to the glutamate-binding site of NMDA receptors, so that the conductance for Ca2+ ions is reduced through a channel blocking the effect of polyphenol PC-8 can be explained. due to its binding to the competing action of the site, the binding of glutamate to NMDA receptors.
Highlights
Take-off from the “Two Cultures” SplitThe traditional, rather sharp separation between and by disciplines is not anymore to be upheld, if not just for operative, methodological or methodical reasons
[Volume-I Issue-VI][Pages = I-XXXVII] [2019] Website: www.usajournalshub.com ISSN (e): 2642-7478 cannot be stopped anymore or scarcely be legally checked. This is certainly true since the last one and a half decades with respect to the world-wide information systems like the Internet, World Wide Web, and other means of data retrieval and access leading to hardly solvable questions of moral responsibility for the data stored or manipulated which cannot be allocated or assigned to a respective one and only bearer of the responsibility anymore
It seems that human responsibility for consequences and developments in comprehensively interconnected and complex information systems can neither ethically nor legally be borne by an individual person any longer nor by a rather vague and almost unlimited set of agents whether individual or group-sized
Summary
The traditional, rather sharp separation between and by disciplines is not anymore to be upheld, if not just for operative, methodological or methodical reasons. This certainly leads to respective challenges on the side of scientific methodologists on the one hand, and of social scientists, social philosophers, and moral philosophers on the other. We all know the problems resulting from the handling of documentation systems, the retrievability of data, the almost unlimited possibility of combining data with respect to data protection problems, respective legislations etc. Some even fear that we are on the brink of or already living in a “computerocracy” – being the fate and development of mass societies which
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