Abstract
Summary A radioautographic technique is described for studying cholesterol transport across a blood vessel wall in a system in vivo and in vitro . A study of the distribution of the tritium-labelled sterol within the intima of the rat aorta demonstrated a concentration of radioactive granules in the intimai cells. The radioactivity within the media in studies both in vivo and in vitro appeared to be concentrated in and adjacent to the smooth muscle cells. These findings are indicative of the important role which these cells play in the transport of cholesterol in the rat arterial wall.
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