Abstract
Vascular complications are the main cause of morbidity and mortality in type 2 diabetic patients. Genetic susceptibility is associated with the evolution of diabetic complications. One such gene is the lamin A and C gene located on chromosome 1q21, a susceptibility locus for type 2 diabetes mellitus, and encodes nuclear lamins A and C. The LMNA 1908 C/T polymorphism has been reported to be associated with dyslipidemia, metabolic syndrome, and obesity, suggesting that this polymorphism increases the risk of atherosclerosis and vascular disease. The present study aims to elucidate the association between the LMNA 1908 C/T single nucleotide polymorphism and the prevalence of vascular complications in a sample of type 2 diabetic Egyptian patients. Genomic DNA from 47 type 2 diabetic patients with vascular complications and 20 control participants was analyzed for the LMNA 1908 C/T polymorphism using PCR- RFLP. Carriers of the LMNA 1908 T-allele showed a significantly higher prevalence in patients with diabetic nephropathy than carriers of the C-allele (P < 0.05). Multiple regression analysis showed that the LMNA 1908 T-allele tended to be independent risk factor for diabetic nephropathy (P = 0.012, odds ratio = 5.460). The findings of this study suggest that the LMNA 1908 C/T single nucleotide polymorphism is associated with the development of diabetic nephropathy in Egyptian type 2 diabetic patients.
Highlights
Type 2 diabetes mellitus is a major health problem worldwide
The BMI and the laboratory parameters among the studied groups are compared in Table 1, which showed statistical significance for fasting blood sugar (FBS), total cholesterol, LDL-C, triglycerides, HOMA, and microalbumin urea in diabetic patients in comparison with the control group
Type 2 diabetes is a major global health problem that affects over 170 million individuals worldwide; it will be certainly one of the major diseases of the 21st century and should be recognized as a priority [4]
Summary
Type 2 diabetes mellitus is a major health problem worldwide. In Egypt, type 2 diabetes is a major health issue. The current prevalence of diabetes in Egypt is among the world’s 10 highest countries. The expected number of individuals with diabetes in Egypt (20–79 age groups) will be 8.6 million in 2030 [1,2,3]. Type 2 diabetes is characterized by peripheral insulin resistance with an insulin-secretory defect that varies in severity. Insulin resistance in the offspring of patients with type 2 diabetes has been known to be the best predictor of the development of the disease [4]
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