Study of the Dopamine Transporter Gene (DAT1) Polymorphism and Serotonin Transporter Promoter Gene in Patients with Lifelong Premature Ejaculation and Its Relation to the Response to SSRIs = دراسة جين ناقل الدوبامين وجين ناقل سيروتونن المحفز في المرضى الذين يعانون من سرعة القذف وعلاقته بالاستجابة لمانع إعادة امتصاص سيروتونن الانتقائي

Abstract

Background: Dopamine and serotonin transporter genes play an important role in the control of the mechanism of ejaculation. Objectives: Evaluation of the role of serotonin transporter gene promoter and dopamine transporter gene polymorphisms in lifelong premature ejaculation and their role in determining the response to paroxetin and escitalopram. Patients and Methods: Eighty consecutive patients and controls were recruited. Forty of them suffered lifelong premature ejaculation. They were divided into two equal groups: One group received paroxetine (20 mg daily)for 1 month, and the other one received ecistalopram (20 mg daily) for 1 month. Their wives were instructed to measure the intravaginal ejaculation latency time using stopwatch. Five ml blood was withdrawn from patients and controls for PCR. Results: The present study revealed that the majority of the patients were SL and SS genotypes of the serotonin transporter gene promoter polymorphism. Also, this study revealed that the majority of the patients were (10R/10R) genotypes of the dopamine transporter gene polymorphism. Both of paroxitine and escitalopram significantly delayed ejaculation in the responders. Conclusion: The study revealed significant association between such response and dopamine transporter gene polymorphism. The present study augmented the significant effect of both paroxetine and escitalopram in delaying ejaculation in the responders.