Abstract
Objective: To study the association between post-traumatic stress disorder (PTSD) and serotonin transporter promoter (5-HTTLPR) gene polymorphism in Han children in Hainan; to explore the genetic mechanism of PTSD in children. Methods: 50 patients with post-traumatic stress disorder and healthy children in Han nationality in Hainan were selected. Detection of 5-HTTLPR gene polymorphism by polymerase chain reaction (PCR) and amplified fragment length polymorphism, the genotype and allele frequencies were analyzed using a case-control association analysis method. Results: There were 4, 14 and 32 cases of LL, SL and SS in the post-traumatic stress disorder group of Hainan Han children, and 13, 20 and 17 cases in the control group. From the perspective of gene frequency, the L gene of post-traumatic stress disorder appeared 22.0%, and S appeared 78.0%. In the control group, L appeared 46.0%, and S appeared 54.0%. There were significant differences in genotype and gene frequency (P < 0.01). Conclusion: The 5-HTTLPR gene polymorphism in Hainan Han children may be associated with post-traumatic stress disorder.
Highlights
The 5-HTTLPR gene polymorphism in Hainan Han children may be associated with post-traumatic stress disorder
The serotonin transporter (5-HTTLPR) is distributed on the presynaptic membrane of 5-HT neurons, which plays an important role in the reabsorption of 5-HT neurotransmitters in the synaptic cleft, 5-HT system functional status [4]
This study further explored the correlation between the genotype and allele frequency of 5-HTTLPR in the post-traumatic stress disorder (PTSD) group and the control group of Han children in Hainan
Summary
Studies have shown that dysfunction of the serotonin system plays a role in the development of children with PTSD. This study further explored the correlation between the genotype and allele frequency of 5-HTTLPR in the PTSD group and the control group of Han children in Hainan. It provides a scientific basis for the clinical diagnosis of children with PTSD and provides a scientific basis for the genetics of PTSD in children
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