Abstract
Trimethoprim is one of the representative drugs within the pharmaceutical and personal care products (PPCPs) group. The photo-Fenton oxidation technology was used to degrade trimethoprim in wastewater and the extent of degradation was analyzed by using high-performance liquid chromatography, then experimentally obtained the optimal conditions. Analysis of the experimental data showed that, under the single-factor experimental conditions, the optimal conditions for degradation were a pH of 4, an H2O2 concentration of 3.0 mmol/L, an FeSO4 concentration of 0.06 mmol/L, an initial trimethoprim concentration of 0.0689 mmol/L, and an ultraviolet (UV) intensity (UVA) of 12 mW/cm2. The interaction of pH and the concentration of H2O2 and Fe2+ have been further explored, it was obtained the following response surface results through the central composite design experiment: pH = 4.56, H2O2 concentration = 0.09 mmol/L, and Fe2+ concentration = 0.09 mmol/L. Under these conditions, it can be obtained a degradation rate of 99.95% after 6 min. There were similar results for three sets of parallel experiments, indicating that these simulation conditions were feasible.
Highlights
With the rapid development of the economy, the problem of environmental pollution became a major research focus
Trimethoprim is a representative antibiotic within the pharmaceutical and personal care products (PPCPs) group and one of the main pollutants in pharmaceutical wastewater, mainly used in synergistic antibacterial activities [13,14]
According to References [20,21], during degradation, noxious nitrogen oxide (NOx) species are released during the Advanced oxidation processes (AOPs) treatment of trimethoprim with several N heteroatoms in its structure
Summary
With the rapid development of the economy, the problem of environmental pollution became a major research focus. Trimethoprim is a representative antibiotic within the PPCP group and one of the main pollutants in pharmaceutical wastewater, mainly used in synergistic antibacterial activities [13,14]. It is used individually in the treatment of respiratory tract infections, urinary tract infections, intestinal infections, and other diseases. According to References [20,21], during degradation, noxious nitrogen oxide (NOx) species are released during the AOP treatment of trimethoprim with several N heteroatoms in its structure It is lower than the concentration of nitrogen in the pollutant, and cannot be considered hazardous. The degradation rate of trimethoprim using the photo-Fenton oxidation technology and the optimal conditions were acquired
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