Study of the association between Urotensin 2 (p.T21M and p.S89N) variants and breast cancer in Egyptian patients

Abstract

BackgroundIn females, breast cancer is the leading cancer regarding both incidence and mortality. Urotensin II (UTS2) is expressed in various tumours, including breast cancer. AimTo study the association between UTS2 (p.T21M and p.S89N) gene variants and breast cancer. Patients and methodsA total of 106 females with breast cancer and 108 age- and sex-matched healthy volunteers were genotyped for UTS2 (p.T21M and p.S89N) variants by TaqMan real-time PCR and PCR-restriction fragment length polymorphism (RFLP), respectively. ResultsThere was no significant difference between cases and controls regarding the distribution of UTS2 p.T21M genotypes. However, frequencies of the heterozygous S/N genotype and the N allele of UTS2 p.S89N were significantly higher in breast cancer patients than in controls (p = 0.018, OR = 5.52, 95% CI = 1.18–25.83; p = 0.020, OR = 5.30, 95% CI = 1.15–24.38, respectively). ConclusionThe UTS2 p.S89N variant but not the UTS2 p.T21M variant is associated with an increased risk of developing breast cancer in Egyptian patients.