Study of surface and bulk physicochemical properties of biocompatible nanoemulsions at T = (293.15,303.15 and 313.15 K)

Abstract

Abstract The physicochemical properties (PCPs) such as viscosity (η), surface tension (γ), friccohesity (σ), particle size (r), zeta potential (ξ) and polydispersity along with the dispersibility and stability assessments are reported for thermodynamically and kinetically stable oil-in-water (o/w) nanoemulsions (NEs) of castor oil (CO), olive oil (OO) and linseed oil (LO) in the presence of cellulose acetate alkanoates stabilizers - cellulose acetate butyrate (CAB) and cellulose acetate propionate (CAP) with cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulphate (SDS) and Tween 20 (Tw20) surfactants at T = 293.15, 303.15 and 313.15 K. The γ, η and ρ data is used to deduce excess surface concentration (Γ ), the area per molecule (Amin), particle size (r), fractional volume (ϕ), activation energy (Ea), and friccohesity (σ) values. This study highlights the role of temperature, structure of oil, surfactants, and stabilizers in the formulation, stability analysis and important physicochemical properties of NEs. Inter-molecular multiple interaction (IMMI) such as electrostatic, hydrogen bonding (HB), cohesive forces (CFs), frictional forces (FFs), Brownian motion, Van der Waals forces and London dispersion forces (LDFs) infer enhanced stability of the NEs. High surface area and biocompatibility make these NEs useful for biological and industrial applications. The measured and calculated PCPs correlate quite well with the stability of biocompatible NEs in terms of solute-solvent interactions (SLS0I) and solute-solute interactions (SLSLI).