Abstract
In recent years, our research team has successfully detected a variety of protein biomarkers for cardiovascular diseases (CVD). The most common type of ischemic heart disease is mainly caused by acute myocardial infarction (AMI, also known as heart attack) usually presented in an acute manner and requires immediate emergency treatment. One of the most important protein biomarkers for AMI in the blood is cardiac troponin I (cTnI). However, in order to develop a cTnI FET sensor that allows patients to track CVD for a long term and often, the instrument must have better sensitivity, stability and reproducibility. In this study, the purpose is understanding the mechanisms contributing to reduce the disturbance in the system. Firstly, the better stability are obtained by adjusting the drain voltage and the gate voltage of the metal oxide semiconductor field effect transistor (MOSFET). It can also be a bias condition for future cTnI FET sensor operation. Although our research team has developed a handheld biomedical sensor, it can not monitor the electrical signal by setting different gate voltages simultaneously. Therefore, Agilent B1530/B1500A is used for measurement. In addition, the Protein detection of different anti-cTnI concentrations also have an great influence on the sensitivity and stability of biomedical sensors. The results of this study can be used as an important basis for optimizing hand-held biomedical sensors in the future. Keyword: Troponin I、Bias condition、Sensitivity、Stability、Reproducibility
Published Version
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