Abstract
According to WHO estimates, 16.7 million people around the globe die of cardiovascular disease each year. Economic transition, urbanization, industrialization and globalization bring about life style changes that promote heart disease. High blood pressure, high cholesterol and obesity are likely to become more prevalent in developing countries. Increased energy intake and sedentary lifestyle are also responsible for heart disease. The presence of one or more cardiovascular risk factors like high levels of TC, LDL, TG, glucose, insulin, BMI and a decreased HDL have been found to increase the progression of prehypertension to hypertension. Prehypertension increases the risk of MI and CAD. The present study was undertaken to know serum lipid profile changes in reproductive and postmenopausal women. Total 60 Subjects of age group 20-45years (reproductive), 46-60years (postmenopausal) female volunteered for our study. During the study period, BMI, Lipid profile, parameters were recorded in all the subjects. In BMI, TC, LDL, VLDL, TG, is gradually increased, HDL is gradually decreased from reproductive age women to post menopausal women. Dyslipidemia occurs due to multifactorial reasons like physical activity, life style, diet, smoking, alcohol consumption, ethnicity and genetic makeup. Post-menopausal women are at increased risk of developing cardiovascular disease due to change in the lipid pattern and loss of cardioprotective effect of estrogen. Predicting the factors affecting the lipid profile in post-menopausal women, adopting strategies to control these mechanisms by modifying the relative risk factors during menopausal transition may improve the cardiovascular risk profile in these women.
 Keyword: Lipid profile, Menopause, Reproductive age group.
Highlights
Menopause is the cessation of menstrual cycle in women
This shows the possible relationship among oestrogen, normal lipid profile and atherosclerosis and the relative immunity to coronary artery diseases (CAD).[5]
Healthy subjects with no evidence of metabolic or endocrinal abnormalities, hypertension or coronary heart disease were selected randomly for reproductive and post menopausal age group consisting of 30 subjects in each group .Total 60 Subjects of age group 20-45years, 46-60 years female volunteered for our study
Summary
Menopause is the cessation of menstrual cycle in women. It represents a transitional phase in the natural biological woman’s age, a natural event that marks the end of the reproductive years of women in terms of the menstrual cycle permanently stopped and the resulting stop ovarian function in females [1]. Menopause is an oestrogen deficient state characterised by permanent amenorrhoea lasting for a period of 1 year due to the cessation of ovarian functions.[3] There is considerable variation in the level of estrogen in postmenopausal women occurs during the early postmenopausal years because of continued secretion of estradiol from the ovary and conversion of androstenedione to estrone in fat tissue.[4] In young women, where oestrogen production is high, serum lipids are normal but after menopause, lipid levels are increased resulting in increased incidence of coronary heart diseases This shows the possible relationship among oestrogen, normal lipid profile and atherosclerosis and the relative immunity to coronary artery diseases (CAD).[5] Natural menopause confers a 3 fold increase in CAD risk and postmenopausal women account for > 30% of the female population at risk for CAD in India.[6,7]. Circulating Serum Cholesterol, Low Cholesterol (LDL-C) and Serum Triglycerides are major
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