Study of Variation in Lipid Profile Parameters in Pre Menopausal and Post Menopausal Subjects

Abstract

Menopause is a phase of woman's natural aging process and is marked by the cessation of ovarian function. The increased incidence of cardiovascular risk in the post-menopausal women may partly be due to hormonal changes leading to derangement of lipid metabolism. The present study is aimed to evaluate the variation in lipid profile in pre-and post-menopausal women. 50 Premenopausal & 50 Postmenopausal women were enrolled in the study after obtaining consent from each patient. Lipid profile was done & compared between both the groups. It was found in study that there is increase in serum Total Cholesterol (TC), Triglycerides (TG), LDL-cholesterol and VLDL-cholesterol level in post-menopausal women as compared to those in pre-menopausal women (p<0.001). HDL-cholesterol level was significantly decreased in post-menopausal women as compared to that in pre-menopausal women (p<0.001). Post-menopausal women are at increased risk of developing cardiovascular disease due to change in the lipid pattern and loss of cardioprotective effect of estrogen. Predicting the factors affecting the lipid profile in post-menopausal women, adopting strategies to control these mechanisms by modifying the relative risk factors during menopausal transition may improve the cardiovascular risk profile in these women.