Study of serum LDH and GGT levels in carcinoma breast

Abstract

Background: Breast cancer is the second most common cancer in women next only to cervical cancer. Multiple factors are associated with an increased risk of developing breast cancer. For the early detection of carcinoma of breast, a number of biochemical markers have been studied to evaluate the malignancy.Aim: To analyse serum Lactate Dehydrogenase, Gamma Glutamyl Transpeptidase, liver enzymes (SGOT, SGPT, & ALP) and total proteins in diagnosis of carcinoma breast patients and compared with controls. And evaluate the relationship of serum LDH, GGT levels with ALP of carcinoma breast patients of post-menopausal age group.Material & Methods: The serum biochemical markers were estimated in 60(30-premenopausal women, 30-post menopausal women) clinically and histopathological confirmed patients with carcinoma breast and 40 number of healthy age- matched individuals served as control. Lactate dehydrogenase (LDH) Serum Gamma Glutamyl Transpeptidase (GGT), were analysed and estimated. Statistics: Data was analysed with student's paired 't'-test was determined.Results: The mean serum LDH, GGT, and ALP activities in patients with carcinoma breast were significantly (p<0.0001) increased as compared to controls, and a steady increase was observed in their levels from premenopausal to post-menopausal women.Conclusion: In this study, it is to suggest that the estimation of LDH, GGT, and ALP can be used as routine screening tests in all suspected carcinoma breast patients and for general population and can detect metastasis.