Abstract
Introduction: Diabetes is a metabolic disorder characterized by hyperglycaemia which is associated with rise in the HbA1c. Excess iron damages ?-cells of pancreas due to oxidative stress which can contribute to pathogenesis of diabetes mellitus. Recent research reveals that HbA1c concentration also increases in iron deficiency anemia as well. This fact is hence important as in diabetic patient, the HbA1c may not be only correlated with blood sugar level but also iron status, if the patient happens to be suffering from iron deficiency anemia. Objectives: Correlation of HbA1c and glucose level with serum ferritin. Materials and Methods: A Cross sectional pilot study was conducted in 80 diabetic patients at Central Clinical Laboratory, MIMER Medical College, Talegaon. Result: There was a positive correlation between serum ferritin and Fasting sugar, postprandial sugar, HbA1c. Serum ferritin is significantly related to Fasting Sugar (P value- 0.0028); postprandial sugar (P value- 0.0118) and glycated Haemoglobin (P value-0.0007). P value Conclusion: Serum ferritin is elevated in patients with type 2 diabetes mellitus and can be used as a marker for glycemic control in diabetic patients. Keywords: Serum ferritin, Glycated haemoglobin, Type 2 diabetes mellitus.
Highlights
Diabetes is a metabolic disorder characterized by hyperglycaemia which is associated with rise in the hemoglobin A1C (HbA1c)
The HbA1c may not be only correlated with blood sugar level and iron status if the patient happens to be suffering from iron deficiency anemia.[20] serum ferritin level had a relationship with hyperglycemia and its level decreased with lowering of serum blood glucose.[21]
The details of patient’s history, clinical presentation, diagnosis and treatment recorded. 1 ml fasting venous sample was collected from subjects in plain bulb for estimation of serum ferritin after written informed consent. 2 ml sample collected in EDTA for HbA1c. 2ml fasting and post-prandial sample in fluoride bulb for blood glucose estimation
Summary
Diabetes is a metabolic disorder characterized by hyperglycaemia which is associated with rise in the HbA1c. Individuals with (T2DM) show both insulin resistance and beta cell defects.[5] The complications of diabetes mellitus are influenced by the duration of the diabetes mellitus and by the average level of blood glucose along with glycated haemoglobin.[2] HbA1c is currently the investigation of choice in monitoring the treatment of diabetes mellitus.[6] Measurement of HbA1c provides valuable information for management of diabetes mellitus[7] but HbA1c may be affected by a variety of genetic, haematologic and illness-related factors[8] like haemoglobinopathies (depending on the assay employed), certain types of anaemia, and disorders associated with accelerated red cell turnover such as malaria.[7,9]
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