Abstract
Diabetes mellitus is a cluster of abnormal metabolic disorder having common features of hyperglycaemia with a state of increased free radical activity. Chronic hyperglycemic status favours auto-oxidation and the formation of advanced glycation end products. Adenosine deaminase (ADA) is considered as a good marker of cell mediated immunity. Increased ADA activity in diabetic individuals could be due to altered insulin related T-lymphocyte function. Hyperglycaemia is associated with increased level of (ADA), which is one of the factor which leads to increase oxidative stress level by generatingthe reactve oxygen species (ROS) leading to insulin resistance. In our study, ADA level was significantly high in controlled diabetes mellitus type 2 (group II with HbA1c < 7) and was much higher in uncontrolled diabetics (group III with HbA1c > 7) compared to healthy controls (group I). The present study was aimed to find the level of Serum (ADA) among the patients with type 2 diabetes mellitus through a case control study and correlation of Adenosine deaminase with glycemic control (HbA1c). Comparison of the parameters fasting plasma glucose (FPG), post prandial plasma glucose (PPPG) HbA1c, and ADA between the 3 groups were done using Student t test and was statistically significant. Pearson’s coefficient correlation was done between ADA and HbA1c and a positive correlaion was seen that was also statistically significant. This indicates that ADA ses with the extent of severity of type 2 diabetes. Positive correlation of ADA with HbA1c provides the information that ADA can be considered to reflect the glycemic status of the individual.
Highlights
Diabetes mellitus (DM) is a chronic endocrine metabolic disorder but largely preventable non communicable disease which is responsible for millions of deaths annually, debilitating complications, and incalculable human misery
The study population comprised of a total of 100 individuals, of which 60 were Diabetic and 40 were healthy controls
All the study individuals were in the age group between 30 and 60 years and individuals in control group were age and sex matched with diabetic cases
Summary
Diabetes mellitus (DM) is a chronic endocrine metabolic disorder but largely preventable non communicable disease which is responsible for millions of deaths annually, debilitating complications, and incalculable human misery. It consistently demonstrates three cardinal abnormalities namely, resistance to the action of insulin in peripheral tissues muscle and adipose tissue, decreased insulin secretion and increased glucose production by the liver. Insulin resistance is decreased biological response to normal concentrations of circulating insulin. It plays a central role in pathophysiology of type 2 Diabetes. Monitoring glycemic control is an essential component of diabetic care [4]. Amongst the various markers of glycemic control, glycated hemoglobin has been established as the most reliable [5]
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