Abstract
Resveratrol, a polyphenolic molecule found in edible fruits and vegetables, shows a wide range of beneficial effects on human health, including anti-microbial, anti-inflammatory, anti-cancer, and anti-aging properties. Due to its poor water solubility and high liposome-water partition coefficient, the biomembrane seems to be the main target of resveratrol, although the mode of interaction with membrane lipids and its location within the cell membrane are still unclear. In this study, using electrophysiological measurements, we study the interaction of resveratrol with planar lipid membranes (PLMs) of different composition. We found that resveratrol incorporates into palmitoyl-oleoyl-phosphatidylcholine (POPC) and POPC:Ch PLMs and forms conductive units unlike those found in dioleoyl-phosphatidylserine (DOPS):dioleoyl-phosphatidylethanolamine (DOPE) PLMs. The variation of the biophysical parameters of PLMs in the presence of resveratrol provides information on its location within a lipid double layer, thus contributing to an understanding of its mechanism of action.
Highlights
Trans 3, 4′, 5-trihydroxystilbene, known as Trans-resveratrol (Figure 1), is found in edible fruits vegetables, in grapes, blueberries, blackberries, peaTrans5-trihydroxystilbene, known as Trans-resveratrol (Figure 1), isand found in nuts.edible fruits and vegetables, in grapes, blueberries, blackberries, and peanuts.2021, 11, 132. https://doi.org/Academic Editor: Monika10.3390/membranes11020132 NaumowiczReceived: 18 January 2021Academic Editor: Monika NaumowiczAccepted: 10 February 2021Published: 14 February 2021
Channel-like event formation indicates that molecules of a substance are incorporating into the membrane
Our results indicate that resveratrol interacts with zwitterionic and neutral planar lipid membranes (PLMs), by incorporating into PLMs and forming transient conductive units, whereas it is unable to interact with DOPE:DOPS PLMs
Summary
Trans 3, 4′, 5-trihydroxystilbene, known as Trans-resveratrol (Figure 1), is found in edible fruits vegetables, in grapes, blueberries, blackberries, peaTrans5-trihydroxystilbene, known as Trans-resveratrol (Figure 1), isand found in nuts.edible fruits and vegetables, in grapes, blueberries, blackberries, and peanuts.2021, 11, 132. https://doi.org/Academic Editor: Monika10.3390/membranes11020132 NaumowiczReceived: 18 January 2021Academic Editor: Monika NaumowiczAccepted: 10 February 2021Published: 14 February 2021. Trans 3, 4′, 5-trihydroxystilbene, known as Trans-resveratrol (Figure 1), is found in edible fruits vegetables, in grapes, blueberries, blackberries, peaTrans. 5-trihydroxystilbene, known as Trans-resveratrol (Figure 1), isand found in nuts. Edible fruits and vegetables, in grapes, blueberries, blackberries, and peanuts
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